Improving the care of patients with rheumatoid arthritis by innovating management strategies, improving the knowledge of the disease, developing biomarkers for diagnosis and prognostication and identifying new potential treatment targets.
Studying and gaining further insight into the utility of modern imaging (e.g. musculoskeletal ultrasound) to improve patient outcomes in rheumatoid arthritis
Clinical trial comparing the outcomes between different methods of injection using ultrasound guidance for frozen shoulder, which is an extremely common condition causing pain and functional debilitation.
S Jayaweera, LC Chew, R Shnier, J Bertouch, A Katrib, F Joshua. A cross-sectional correlation of enthesitis of the elbow and Achilles in Ankylosing Spondylitis with ultrasound and MRI. Internal Medicine Journal (Royal Australasian College of Physicians) 2012;42 (Suppl.1): 9-35.
Tjeuw M, Chew L, Joshua F, Katrib A, Bertouch J Intermachine Reliability for Detection of Power Doppler Signal in Rheumatoid Arthritis. Internal Medicine Journal (Royal Australasian College of Physicians) 2011 41(Suppl.1):20-21.
Peter Cheung, Kok Ooi Kong, Li-Ching Chew, Faith L. Chia, Weng Giap Law, Tsui Yee Lian, York Kiat Tan, Yew Kuang Cheng. Achieving consensus in ultrasonography synovitis scoring in rheumatoid arthritis. International Journal of Rheumatic Diseases 2014 13;17(7),776-78.
Li-Ching Chew, P Chandra Mohan, Lai Peng Chan, Kok Yong Fong, Julian Thumboo. The Use of Magnetic Resonance Imaging in Detecting Subclinical Synovitis in Rheumatoid Arthritis and Correlation of Imaging Findings with Interleukin-18 levels. International Journal of Rheumatic Diseases, 2014 19(8):790-798.
Tan YK, Allen JC Jr, Lye WK, Conaghan PG, D'Agostino MA, Chew LC, J Thumboo. Novel Ultrasound Joint Selection Methods Using a Reduced Joint Number Demonstrate Inflammatory Improvement when Compared to Existing Methods and Disease Activity Score at 28 Joints. J Rheumatol. 2016 1;43(1):34-7.
Tan YK, Chew LC, Allen JC Jr, Lye WK, Htay LL, Hassan A, Conaghan PG, Thumboo J. Utility of ultrasonography in guiding modification of disease modifying anti-rheumatic drugs and steroid therapy for inflammatory arthritis in routine clinical practice. Int J Rheum Dis. 2018 19;21(1):155-160.
Tan YK, Allen JC Jr, Lye WK, Conaghan PG, Chew LC, J Thumboo. Dichotomous versus semi-quantitative scoring of ultrasound joint inflammation in rheumatoid arthritis using novel individualized joint selection methods. Clin Rheumatol 2017 36(5):1137–1141.
Allen, J. C., Thumboo, J., Lye, W. K., Conaghan, P. G., Chew, L.-C., Tan, Y. K. Novel joint selection methods can reduce sample size for rheumatoid arthritis clinical trials with ultrasound endpoints. Int J Rheum Dis. 2018 3;21(3):693-698.
York Kiat Tan, John C. Allen Jr, Weng Kit Lye, Li-Ching Chew, Julian Thumboo. Greater rheumatoid arthritis joint improvement with more subjects achieving response across improvement categories using novel versus existing ultrasound methods. Rheumatol Int 2018 20;38(5):795-799.
Mona Manghani, Peter P. Cheung, Sreenivasulu Reddy Mogali, Ashutosh Prakash, and Li-Ching Chew. An evaluation of the effectiveness of teaching anatomy to rheumatologists through combined musculoskeletal sonoanatomy and human cadaveric dissection. Rheumatology Advances in Practice 2020;0:1–5 https://doi.org/doi:10.1093/rap/rkaa010.
