Regorafenib

• Palms of the hands or soles of the feet become numb, sore, red or dry
• Diarrhea, stomach discomfort
• Nausea, decreased appetite
• Mouth sores or ulcers
• High blood pressure
• Tiredness or lack of energy
• Increased risk of infection
  Maintain hygiene, avoid crowds and people with infection. 
• Voice change or hoarseness

Inform your doctor if any of the following occurs:

• Painful blistering or swelling of hands or feet
• Signs of unusual bleeding e.g. unexplained bruises or black, sticky stools
• Chest pain or tightness, shortness of breath
• Yellowing of the skin or eye, or dark tea-coloured urine
• Severe abdominal pain, nausea, vomiting
• Fever of 38 ˚C or higher
• Severe headache, giddiness, confusion or change in vision

• Use effective birth control during treatment and for at least 2 months after stopping Regorafenib. Inform your doctor if you or your partner plan for or suspect pregnancy.
• Inform your doctor or pharmacist if you:
• Have any surgery planned.
• Have any other medical conditions e.g. high blood pressure, heart problems.
• Are taking any other medication or supplements.