Regorafenib

• Palms of the hands or soles of the feet become numb, sore, red or dry
• Diarrhea, stomach discomfort
• Nausea, decreased appetite
• Mouth sores or ulcers
• High blood pressure
• Tiredness or lack of energy
• Increased risk of infection
  Maintain hygiene, avoid crowds and people with infection. 
• Voice change or hoarseness

Inform your doctor if any of the following occurs:

• Painful blistering or swelling of hands or feet
• Signs of unusual bleeding e.g. unexplained bruises or black, sticky stools
• Chest pain or tightness, shortness of breath
• Yellowing of the skin or eye, or dark tea-coloured urine
• Severe abdominal pain, nausea, vomiting
• Fever of 38 ˚C or higher
• Severe headache, giddiness, confusion or change in vision

• Use effective birth control during treatment and for at least 2 months after stopping Regorafenib. Inform your doctor if you or your partner plan for or suspect pregnancy.
• Inform your doctor or pharmacist if you:
• Have any surgery planned.
• Have any other medical conditions e.g. high blood pressure, heart problems.
• Are taking any other medication or supplements.

It is a tablet, taken by mouth and swallowed whole with water after a light (low-fat) meal. Take once daily at around the same time each day for 3 weeks out of a 4-week cycle.

Take the exact number of tablets instructed by your doctor.

If you miss a dose, take it as soon as you can on the same day and then go back to your usual dosing time the next day. Do not double dose.

If you overdose on this medication, inform your doctor immediately.

Do not break or crush the tablets.