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Colorectal Cancer

Colorectal Cancer - Causes and Risk Factors

The exact cause of colorectal cancer is not known but certain risk factors such as age, having certain medical conditions, inherited genetic syndromes, diet and lifestyle can contribute to the development of colorectal cancer. 

Having risk factors increases the likelihood of developing the colorectal cancers but it does not guarantee that the condition will develop. Understanding risk factors can help with prevention and recommended screening. 

Factors that can increase the risk of colorectal cancer include: 
  • Older age – Colorectal cancer is often diagnosed in people aged 50 years and above. However, younger people can also be diagnosed with the cancer. 
  • History of colorectal polyps or cancer – Having colorectal polyps or cancer in the past increases the risk of developing colorectal cancer. 
  • Inflammatory bowel diseases – Having ulcerative colitis, Crohn’s disease or other diseases that cause inflammation of the intestines can increase the risk of developing colorectal cancer. 
  • Family history of cancer or conditions – Having one or more blood relatives, who have had colorectal cancer or an inherited condition such as Lynch syndrome or familial adenomatous polyposis, increases the risk of developing the disease. 
  • Diabetes - Having diabetes and insulin resistance elevates the risk of developing colorectal cancer. 
  • A low-fibre, high fat diet – Some research has shown that eating a diet low in fibre and high in fat and calories, a typical Western diet, increases the risk of developing colorectal cancer. 
  • A sedentary lifestyle – Being inactive and not engaging in regular physical activity can increase the risk of developing the disease. 
  • Smoking – As with most cancers, smoking is a risk factor for developing colorectal cancer. 
  • Heavy use of alcohol – Drinking copious amounts of alcohol can increase the risk of colorectal cancer. 
There are some complications that may arise as colorectal cancer progresses and even after treatment. These include: 
  • Bowel obstruction can happen when the tumour grows and blocks the intestines 
  • Low blood counts may result from blood losses from bleeding tumours 
  • Cancer spread or metastases to other organs, such as the liver, lungs, peritoneum and lymph nodes. 
  • Cancer recurrence is when cancer develops again after initial treatment and remission. A recurrence may develop at the same site of the previous colorectal cancer or may spread and develop in other organs.

Our Care Team

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Claramae Chia Shulyn Clin Assoc Prof

Clin Assoc Prof Claramae Chia Shulyn

Senior Consultant

 MBBS (S'pore), MRCS (Edin), MMed (Surgery), FRCS (Edin)

Clinical Interests: Upper Gastrointestinal, Colorectal, Peritoneal-based Malignancies, Sarcoma, Skin & Melanoma, Gastrointestinal, Gastrointestinal Oncology, General Surgery, Melanoma, Pelvic & Peritoneal, Sarcoma/Skin

Emile John Tan Kwong Wei  Prof

Prof Emile John Tan Kwong Wei

Head & Senior Consultant

​BSc (Hons), MBBS (London), MD (Research)(Imperial College London), FRCS (General/Colorectal) UK

Clinical Interests: Colorectal Surgery, Inflammatory Bowel Disease, Pelvic Floor Disorders, Disease of the Anus, Endoscopy, Minimally Invasive Surgery – Robotic and Laparoscopic Surgery

Cherylin Fu Clin Asst Prof

Clin Asst Prof Cherylin Fu

Senior Consultant

MBBS, MRCSEd, MMed (Surg), FRCSEd (Gen Surg)

Clinical Interests: Transanal Total Mesorectal Excision (taTME), Pelvic Floor Disorders, Natural Orifice Specimen Extraction, Advanced Minimally Invasive Colorectal Surgery

Chang Meihuan Dr

Dr Chang Meihuan

Senior Consultant

MBBS (Singapore), MMed (Surg), FRCS (Ed)

Clinical Interests: Colorectal Surgery, Proctology, Endoscopy, Minimally Invasive Surgery – Robotic and Laparoscopic Surgery

Isaac Seow-En Dr

Dr Isaac Seow-En

Senior Consultant

MBBS (Singapore), MMed (Surgery), FRCS (Edinburgh)

Clinical Interests: Surgery & Surgical Oncology

Ong Chin-Ann Johnny Assoc Prof

Assoc Prof Ong Chin-Ann Johnny

Senior Consultant

MBBS (S'pore), MRCS (Ed), M Med (Surgery), FRCS (Ed), PhD (Cambridge)

Clinical Interests: Peritoneal-based Malignancies, Sarcoma, Skin & Melanoma, Colorectal, Gastrointestinal, Gastrointestinal Oncology, General Surgery, Gynae-Oncology, Lymphoma (DMO, DRO), Melanoma, Pelvic & Peritoneal, Sarcoma/Skin, Supportive & Palliative Care, Upper Gastrointestinal

Tang Choong Leong Assoc Prof

Assoc Prof Tang Choong Leong

Senior Consultant

MBBS (Singapore), MMed (Surg), FRCS (Ed), FAMS

Clinical Interests: Colorectal Surgery, Inflammatory Bowel Disease, Pelvic Floor Disorders, Proctology, Endoscopy, Minimally Invasive Surgery – Laparoscopic Surgery

Koo  Chee Hoe Dr

Dr Koo Chee Hoe

Consultant

​MBBS (Singapore), MMed (Surgery), FRCS (Ed)

Clinical Interests: Colorectal Surgery, Proctology, Endoscopy

Lin Wenjie Dr

Dr Lin Wenjie

Consultant

​MBBS (Singapore), MMed (Surgery), FRCS (Ed)

Clinical Interests: Colorectal Surgery, Proctology, Endoscopy

Lionel  Raphael Chen Hui Dr

Dr Lionel Raphael Chen Hui

Consultant

​MBBS (Singapore), MMed (Surgery), FRCS (Ed)

Clinical Interests: Colorectal Surgery, Proctology, Endoscopy

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