Aminosalicylates

Drug Class:	Commonly Known As:	Category:
Aminosalicylates	Salofalk ® (Mesalazine EC); Pentasa ® (Mesalazine PR); Salofalk ® (Mesalazine) Rectal Foam; Sulfasalazine EC	Adult

Aminosalicylates - Side Effects, Precautions, and Contraindications

What side effects can Aminosalicylates cause?

You may experience the following side effects while on Aminosalicylates. Tell your doctor if you encounter any of them so that adjustments to your therapy may be made to reduce the occurrence of these side effects where possible. These include:

	Sulfasalazine	Mesalazine (Oral)
Common	Nausea and vomiting Headache and dizziness Abdominal pain and indigestion Diarrhea Orange/ yellow discoloration of urine or perspiration from skin. Extended wear soft contact lens may be permanently stained yellow Metallic taste in mouth Mild rash and itchiness Drug fever- due to sulfa component	Nausea and vomiting Headache and dizziness Abdominal pain and indigestion Diarrhea Mild rash and itchiness
Less common/ rare	Decrease in sperm production (reversible once stopped) Yellowing of skin, eye Pins and needles in hands and feet Bone marrow suppression - manifested as sore throat, mouth ulcers, unexplained bruising/bleeding, unusual tiredness, prolonged infection or fever Ringing in ears Increased sensitivity to sun - apply sunscreen Reversible lung inflammation manifested as breathlessness Depression Kidney pain/ inflammation Pancreatitis manifested as severe abdominal pain	Yellowing of skin, eye Bone marrow suppression - manifested as sore throat, mouth ulcers, unexplained bruising/bleeding, unusual tiredness, prolonged infection or fever Kidney pain/ inflammation Pancreatitis manifested as severe abdominal pain

If you experience any severe signs of illness, or side effects such as unexplained bruising, bleeding (nosebleeds), sore throat, fever or malaise, severe abdominal pain, or a blistering skin rash contact your doctor immediately.