Myelofibrosis

Myelofibrosis - Treatments

Issues in patients with myelofibrosis include:

Anaemia
Treatment for anaemia includes danazol, erythropoietin, immunomodulatory agents (iMiDs) and blood transfusion
High blood counts: hydroxyurea, anagrelide, PEGylated interferon
Enlarged spleen: JAK inhibitors (ruxolitinib), radiotherapy to the spleen, splenectomy
Constitutional symptoms such as fatigue and night sweats: ruxolitinib

For younger patients with advanced or poor risk myelofibrosis, allogeneic hematopoietic stem cell transplant may be a consideration because transplant is the only treatment that can potentially cure myelofibrosis.

SGH has extensive expertise in treating MPNs. As the largest hospital in Singapore treating MPNs, it is a one stop comprehensive care centre with clinical and laboratory facilities for diagnosis and monitoring of treatment. We offer state of the art therapies with the possibility of participation in local and international clinical trials. Patients receive holistic care, individualized to their condition and preferences.

Myelofibrosis - Preparing for surgery

Myelofibrosis - Post-surgery care

Myelofibrosis - Other Information

Pegylated Interferon alpha-2a,

Ruxolitinib

Article contributed by Haematology, Singapore General Hospital

The information provided is not intended as medical advice. Terms of use. Information provided by SingHealth

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