In localised endocrine tumours, treatment involves resection. This may involve a Whipples operation for tumours in the head of the pancreas, or a distal pancreatectomy (with or without splenectomy) for tumours in the body and/or tail.
Occasionally, in small, asymptomatic tumours, close observation may be considered. However, before choosing this option, it is important to establish the diagnosis definitively, and ensure that the tumour has non-aggressive features.