Profile
Dr Xiao is Junior Principal Investigator (PI) at NNI and Assistant Professor at Duke-NUS Medical School. Dr Xiao is a trained neurologist specialising in movement disorders. He focuses his research on biomarker and actionable target in neurodegenerative diseases in attempt to develop therapeutic option that may reverse pathogenesis of such conditions, including Parkinson's disease.
Education
- PhD (Molecular Neuroscience)
- MMed (Neurology)
- MBBS
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Professional Appointments and Committee Memberships
- Junior Principal Investigator, National Neuroscience Institute
- Assistant Professor, Duke-NUS Medical School
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Awards
- Gold Award, Best Junior Researcher, National Neuroscience Institute, 2022
- Open-Fund Young Individual Research Grant, NMRC Awards, 2021
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Research Interests
- Biomarker and therapeutic strategy in neurodegenerative diseases
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Publications
- Xiao B, Tan EK. Targeting LRRK2 in Parkinson's disease. Cell reports. Medicine. Oct 18 2022;3(10):100778.
- Xiao B, Kuruvilla J, Tan EK. Mitophagy and reactive oxygen species interplay in Parkinson's disease. NPJ Parkinsons Dis. Oct 18 2022;8(1):135.
- Deng X, Saffari SE, Liu N, et al. Biomarker characterization of clinical subtypes of Parkinson Disease. NPJ Parkinsons Dis. Aug 29 2022;8(1):109.
- Jo J, Yang L, Tran HD, et al. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations. Ann Neurol. Sep 2021;90(3):490-505.
- Deng X, Xiao B, Allen JC, et al. Parkinson's disease GWAS-linked Park16 carriers show greater motor progression. J Med Genet. Nov 2019;56(11):765-768.
- Xiao B, Deng X, Ng EY, et al. Association of LRRK2 Haplotype With Age at Onset in Parkinson Disease. JAMA Neurol. Jan 1 2018;75(1):127-128.
- Xiao B, Goh JY, Xiao L, et al. Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin. J Biol Chem. Oct 6 2017;292(40):16697-16708.
- Xiao B, Deng X, Ng EY, et al. GWAS-linked PPARGC1A variant in Asian patients with essential tremor. Brain. Apr 1 2017;140(4):e24.
- Xiao B, Deng X, Lim GGY, et al. p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization. Biochim Biophys Acta Mol Cell Res. Jul 2017;1864(7):1308-1317.
- Xiao B, Deng X, Lim GGY, et al. Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria. Cell Death Dis. Oct 12 2017;8(10):e3097.
- Xiao B, Ng HH, Takahashi R, Tan EK. Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges. J Neurol Neurosurg Psychiatry. Jul 2016;87(7):697-702.
- Xiao B, Deng X, Zhou W, Tan EK. Flow Cytometry-Based Assessment of Mitophagy Using MitoTracker. Front Cell Neurosci. 2016;10:76.
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