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Asst Prof Tiew Pei Yee

MBBS, PHD

Senior Consultant

Singapore General Hospital

Specialty: Respiratory and Critical Care Medicine

Clinical Interest: Chronic Obstructive Pulmonary Disease, Asthma

Conditions Treated by this Doctor:
Asthma, Bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD), Severe Asthma, Severe Asthma.

Clinical Appointments

Senior Consultant Respiratory ＆ Critical Care Medicine Singapore General Hospital

Academic Appointments

Assistant Professor Lee Kong Chian School of medicine and Duke-NUS Medical School Singapore

Profile

Dr Tiew is a Senior Consultant of the Department of Respiratory and Critical Care Medicine. She leads the COPD Clinic at SGH, focusing on advancing patient care and outcomes. Her primary clinical and research interests are in chronic airway diseases, particularly COPD and severe asthma. Dr. Tiew has received competitive grants, including the NMRC Research Training Fellowship and the Transition Award, to support her research in this field.

Education

Professional Appointments and Committee Memberships

Awards

Research Interests

COPD, Asthma, Bronchiectasis, microbiome, Mycobiome, fungal sensitization

Publications

Ivan FX, Tiew PY, Jaggi TK, Thng KX, Pang PH, Ong TH, Abisheganaden JA, Koh MS, Chotirmall SH. Sputum metagenomics reveals a multidrug resistant Pseudomonas-dominant severe asthma phenotype in an Asian population. Respirology. 2024 Dec 2. doi: 10.1111/resp.14863. Epub ahead of print. PMID: 39622769.
Jaggi TK, Agarwal R, Tiew PY, Shah A, Lydon EC, Hage CA, Waterer GW, Langelier CR, Delhaes L, Chotirmall SH. Fungal Lung Disease. Eur Respir J. 2024 Oct 3:2400803.
Puan Y, Ong KY, Tiew PY, Chen GXW, Teo NWY, Low AHL, Wechsler ME, Koh MS. Characteristics of Severe Asthma Clinic Patients with Eosinophilic Granulomatosis with Polyangiitis. J Allergy Clin Immunol Pract. 2024 Oct 16:S2213-2198(24)01067-5
Tiew PY, Leung JM, Mac Aogáin M, Johal P, Jaggi TK, Yuen ACY, Ivan FX, Yang J, Afshar T, Tee A, Koh MS, Lim YH, Wong A, Chandrasekaran L, Dacanay JG, Drautz-Moses DI, Ong TH, Abisheganaden JA, Chew FT, Schuster SC, Carlsten C, Chotirmall SH. Residential exposure to Aspergillus spp. is associated with exacerbations in COPD. Eur Respir J. 2024 Oct 10:2400907.
Mac Aogáin M, Tiew PY, Jaggi TK, Narayana JK, Singh S, Hansbro PM, Segal LN, Chotirmall SH. Targeting respiratory microbiomes in COPD and bronchiectasis. Expert Rev Respir Med. 2024 Mar-Apr;18(3-4):111-125.
Tiew PY, Tay TR, Chen W, Price DB, Ong KY, Chotirmall SH, Koh MS. Predictors of persistent poor control and validation of ASSESS score: Longitudinal 5-year follow-up of severe asthma cohort. J Allergy Clin Immunol Glob. 2023 Nov 20;3(1):100188.
Mugunthan S, Wong LL, Winnerdy FR, Summers S, Bin Ismail MH, Foo YH, Jaggi TK, Meldrum OW, Tiew PY, Chotirmall SH, Rice SA, Phan AT, Kjelleberg S, Seviour T. RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms. Nat Commun. 2023 Nov 27;14(1):7772. (JIF:16.6)
Tiew PY, Oliver W. Meldrum, Sanjay H.Chotirmall. Applying Next-Generation Sequencing and Multi-Omics in Chronic Obstructive Pulmonary Disease. Int. J. Mol. Sci. 2023, 24(3),2955 (JIF:6.208)
Chan LLY, Anderson DE, Cheng HS, Ivan FX, Chen S, Kang AEZ, Foo R, Gamage AM, Tiew PY, Koh MS, Lee KCH, Nichol K, Pathinayake PS, Chan YL, Yeo TW, Oliver BG, Wark PAB, Liu L, Tan NS, Wang LF, Chotirmall SH. The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi. Nat Commun. 2022 Dec 10;13(1):7635. (JIF: 17.69)
Ong KY, Tiew PY, MS Koh Managing adult asthma during the COVID-19 Pandemic: A 2022 review and current recommendations. Ann Acad Med Singap. 2022 Oct;51(10):637-647. (JIF: 8.713)
Lim GN, Allen JC, Tiew PY, Chen W, Koh MS. Healthcare utilisation and health-related quality of life of severe asthma patients in Singapore. J Asthma. 2022 Aug 16:1-20. (JIF:2.515)
Tiew PY, Narayana JK, Li Quek MS, Ang YY, San Ko FW, Poh ME, Jaggi TK, Xu H, Thng KX, Koh MS, Tee A, Cheong Hui DS, Abisheganaden JA, Tsaneva-Atanasova K, Chew FT, Chotirmall SH. Sensitisation to recombinant Aspergillus fumigatusallergens and clinical outcomes in COPD. Eur Respir J. 2022 Aug 4:2200507. (JIF: 33.8)
Tiew PY, KX Thng, Sanjay H Chotirmall. Clinical Aspergillus Signatures in COPD and bronchiectasis. J Fungi (Basel). 2022 May 5;8(5):480. (JIF:5.816)
Kam MLW, Tiew PY, Chai HZ, Low SY. Cluster phenotypes in a non-idiopathic pulmonary fibrosis fibrotic interstitial lung diseases cohort in Singapore. J Thorac Dis. 2022 Jul;14(7):2481-2492. (JIF :3.005)
Tiew PY, Mac Aogáin M, Sanjay H Chotirmall. The current understanding and future directions for sputum microbiome profiling in chronic obstructive pulmonary disease. Curr Opin Pulm Med 2022 Mar 1;28(2):121-133 (JIF:2.6).
Tiew PY, Lim AYH, Keir HR, Dicker AJ, Mac Aogain M, Pang SL, Low TB, Hassan T, Poh ME, Xu HY, Ong TH, Koh MS, Abisheganaden JA, Tee A, Chew FT, Chalmers JD, Chotirmall S. High Frequency of Allergic Bronchopulmonary Aspergillosis in Bronchiectasis-COPD Overlap. Chest 2022 Jan;161(1):40-53. (JIF:10.262).
Yoon S, Goh H, Chan A, Malhotra R, Visaria A, Matchar D, Lum E, Seng B, Ramakrishnan C, Quah S, Koh MS, Tiew PY, Bee YM, Abdullah H, Nadarajan GD, Graves N, Jafar T, Ong MEH. Spillover Effects of COVID-19 on Essential Chronic Care and Ways to Foster Health System Resilience to Support Vulnerable Non-COVID Patients: A Multistakeholder Study. J Am Med Dir Assoc 2022 Jan; 23 (1):7-14. (JIF:7.802).
Yoon S, Hoe PS, Chan A, Malhotra R, Visaria A, Matchar D, Goh H, Seng B, Ramakrishnan C, Koh MS, Tiew PY, Nadarajan GD, Bee YM, Graves N, Jafar TH, Ong ME. Impact of COVID-19 on perceived wellbeing, self-management and views of novel modalities of care among medically vulnerable patients in Singapore. Chronic Illn. 2021 Dec 29:17423953211067458. (JIF:2.409).
Tiew PY, Mac Aogáin M, Ter SK, Aliberti S, Chalmers JD, Chotirmall SH. Respiratory Mycoses in COPD and Bronchiectasis. Mycopathologia. 2021 Oct;186(5):623-638. (JIF: 2.574).
Young SL, Puan Y, Chew SY, Haja Mohideen SM, Tiew PY, Tan GL, Koh MS, Lee KCH. Heterogeneity of non-cystic-fibrosis bronchiectasis in multiethnic Singapore: A prospective cohort study at a tertiary pulmonology centre. Ann Acad Med Singap 2021 Jul;50(7):556-565. (JIF:8.713).
Mac Aogáin M, Narayana JK, Tiew PY, Ali NABM, Yong VFL, Jaggi TK, Lim AYH, Keir HR, Dicker AJ, Thng KX, Tsang A, Ivan FX, Poh ME, Oriano M, Aliberti S, Blasi F, Low TB, Ong TH, Oliver B, Giam YH, Tee A, Koh MS, Abisheganaden JA, Tsaneva-Atanasova K, Chalmers JD, Chotirmall SH. Integrative microbiomics in bronchiectasis exacerbations. Nature Medicine 2021 Apr; 27(4):688-699. (IF:53.44).
Tiew PY, Dicker AJ, Keir HR, Poh M E, Pang SL, Mac Aogain M, Chua BQY, Xu H, Koh MSY, Tee A, Abisheganaden JA, Chew FT, Miller BE, Tal-Singer R, Chalmers JD, Chotirmall SH. A High-risk Airway Mycobiome is associated with Frequent Exacerbation and Mortality in COPD. Eur Respir J 2021 Mar 11;57:2002050. (JIF: 33.8).
Tiew PY, Tavleen K Jaggi, Louisa L Y Chan, Sanjay H Chotirmall. The airway microbiome in COPD, bronchiectasis and bronchiectasis-COPD overlap. Clinical Respiratory Journal 2021 Feb;15(2):123-133. (JIF 1.761).
Tiew PY, Karen Li Leng Tan, Mariko Siyue Koh. FDA boxed warning for Montelukast: Impact on adult severe asthmatics? Annals Academy of Medicine Singapore 2020 Dec; 49(12):1029-1030. (JIF :8.713)
Tiew PY, Ko FWS, Pang SL, Matta SA, Sio YY, Poh ME, Lau KJX, Mac Aogain M, Jaggi TK, Ivan FX, Gaultier NE, Uchida A, Drautz-Moses DI, Xu H, Koh MS, Shu DCH, Tee A, Abisheganaden JA, Schuster ST, Chew FT and Chotirmall SH. Environmental Fungal Sensitisation Associates with Poor Clinical Outcomes in COPD. Eur Respir J 2020 Aug 27; 56(2):2000418. (JIF:33.8).
Poh T Y, Tiew PY, Lim, AYH, Thng KX, Ali NABA, Narayana JK, Mac Aogáin M, Tien Z, Chew WM, Chan AKW, Keir H, Dicker A, Hassan T, Xu, H, Tee A, Ong TH, Koh MS, Abisheganaden JA, Chalmers J, Chotirmall SH. Increased chitotriosidase is associated with Aspergillus and frequent exacerbations in South-East Asians with bronchiectasis. Chest. 2020 Aug;158(2):512-522. (JIF:10.262).
Mac Aogáin M, Lau KJX, Cai Z, Narayana JK, Purbojati RW, Drautz-Moses DI, Gaultier NE, Jaggi TK, Tiew PY, Ong TH, Koh MS, Hou ALY, Abisheganaden JA, Tsaneva-Atanasova K, Schuster SC, Chotirmall SH. Metagenomic Reveals aCore Macrolide Resistome Related to Microbiota in Chronic Respiratory Disease. Am J Respir Crit Care Med. 2020 Aug 1;202(3):433-477. (JIF: 30.528).
Tiew PY, Ko FWS, Narayana JK, Poh ME, Xu H, Neo HY, Loh LC, Ong CK, Mac Aogáin M, Ying Tan JH, Kamaruddin NH, Hui Sim GJ, Lapperre TS, Koh MS, Cheong Hui DS, Abisheganaden JA, Tee A9, Tsaneva-Atanasova K, Chotirmall SH. “High Risk' Clinical And Inflammatory Clusters In Copd Of Chinese Descent. Chest. 2020 Jul;158(1):145-56. (JIF:10.262).
Poh TY, Ali NABM, Chan L L.Y., Tiew PY, Chotirmall S H. Evaluation of droplet digital polymerase chain reaction (ddPCR) for the absolute quantification of Aspergillus species in the human airway. Int J Mol Sci. 2020 Apr 26;21(9):3043. (JIF:6.208).
Tiew PY, Mac Aogáin M, Ali NABM, Thng KX, Goh K , Lau KJX, Chotirmall SH. Mycobiome in health and disease: Emerging Concepts, Methodologies and Challenges. Mycopathologia. 2020 Apr;185(2):207-231 (JIF: 2.574).
*Mac Aogáin M, * Tiew PY, Lim AYH, Low TB, Tan GL, Hassan T, Ong TH, Pang SL, Lee ZY, Gwee XW, Martinus C, Sio YY, Matta SA, Ong TC, Tiong YS, Wong KN, Narayanan S, Bijin Au V, Marlier D, Keir HR, Tee A, Abisheganaden JA, Koh MS, Wang Y, Connolly JE, Chew FT, Chalmers JD, Chotirmall SH. Distinct 'Immuno-Allertypes' of Disease and High Frequencies of Sensitisation in Non-Cystic-Fibrosis Bronchiectasis. Am J Respir Crit Care Med. 2019 Apr 1;199(7):842-853. (JIF: 30.528) (*Joint first author).
Ali NABM, Mac Aogáin M, Morales RF, Tiew PY, Chotirmall SH. Optimisation and Benchmarking of Targeted Amplicon Sequencing for Mycobiome Analysis of Respiratory Specimens. Int J Mol Sci. 2019 Oct 9;20(20). (JIF:6.208).
Anthony CA Yii, Sean CH Loh, Tiew PY, Huiying Xu, Aza Taha, Jansen Koh, Jessica Tan HY, Therese Lapperre, Antonio Anzueto, Augustine KH Tee. A clinical prediction model for hospitalized COPD exacerbations based on “treatable traits”. Int J Chron Obstruct Pulmon Dis. 2019 Mar 27; 14:719-728. (JIF:3.355).
*Leung JM, *Tiew PY, Mac Aogáin M, Budden KF, Yong VF, Thomas SS, Pethe K, Hansbro PM, Chotirmall SH. (*Joint first author). The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD. Respirology.2017 May;22(4):634-650. (JIF: 6.175).
Poh TY, Mac Aogáin M, Chan AK, Yii AC, Yong VF, Tiew PY, Koh MS, Chotirmall SH. Understanding COPD-overlap syndromes. Expert Rev Respir Med. 2017 Apr;11(4):285-298. (JIF: 2.432).
Mok Y, Tan TY, Tay TR, Wong HS, Tiew PY, Kam JW, Siao C. Do we need transbronchial lung biopsy if we have bronchoalveolar lavage Xpert® MTB/RIF? Int J Tuberc Lung Dis. 2016 May;20(5):619-24. (JIF: 2.373).
Poulose V, Tiew PY, How CH. Approaching chronic cough. Singapore Med J. 2016 Feb;57(2):60-3. (JIF: 1.08).
Tiew PY, Oh CC, Al Jajeh I, Lee HY. Eruptive Nodules in a Patient with Marginal Zone Lymphoma. Clin Exp Dermatol. 2014 Dec;39(8):949-51 (JIF :1.484).

Research Trials

Tags: Respiratory and Critical Care Medicine, Chronic Obstructive Pulmonary Disease, Asthma, Asthma, Bronchiectasis, Chronic Obstructive Pulmonary Disease (COPD), Severe Asthma, Severe Asthma