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Clin Assoc Prof Linn Yeh Ching

MBBS, MRCP(UK)

Senior Consultant

Singapore General Hospital

Specialty: Haematology

Clinical Interest: Haematopoietic Stem Cell ＆ Cellular Therapy

Conditions Treated by this Doctor:
Acute Leukaemia, Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia, Deep Vein Thrombosis, Deep Vein Thrombosis, Essential Thrombocythemia and Myelofibrosis, Multiple Myeloma, Myelodysplastic Syndrome, Myelofibrosis, Polycythemia Vera, Pulmonary Embolism, Thalassaemia.

Clinical Appointments

Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
Senior Consultant SingHealth Duke-NUS Transplant Centre
Senior Consultant Haematology Singapore General Hospital
Senior Consultant National Cancer Centre Singapore

Profile

Dr Linn Yeh Ching graduated from NUS in 1987 and obtained her MRCP (UK) in 1991.

She has been working in the Dept of Haematology since then and is actively involved in clinical service, research and teaching. Her areas of interest are in haemopoietic stem cell transplantation and cellular immunotherapy.

She has published on various transplant related areas, cytokine-induced killer (CIK) cells and virus-specific T cells. She is principal investigator of clinical studies on use of CIK cells for leukemia post autologous and allogeneic haemopoietic stem cell transplantation in adjuvant and salvage setting, with fundings from National Medical Research Council and SingHealth Research Funds.

She also has a keen interest Traditional Chinese Medicine from the perspectives of evidence – based medicine and its safe use with Western Medicine.

Education

MBBS/1987, National University of Singapore
MRCP(UK)/1991, Royal College of Physician, UK

Professional Appointments and Committee Memberships

Clinical Senior Lecturer, Yong Loo Lin School of Medicine, National University of Singapore
Adjunct Associate Professor, Duke-NUS Medical School, Singapore

Awards

Research Interests

haemopoietic stem cell transplantation
cellular immunotherapy

Publications

Yeh-ching Linn, Kirubavathy Sundar Raj, Bryan Teo, Chew-Yen Phang, Manesh Chittezhath, Mickey Koh. A cost-effective strategy for selection of third-party donors for a virus-specific T-cell bank for an Asian patient population Cytotherapy 2023; 25(5): 510-520
Wing Leung, Teck Guan Soh, Yeh Ching Linn, Jenny Guek-Hong Low, Jiashen Loh, Marieta Chan, Wee Joo Chng, Liang Piu Koh, Michelle Li-Mei Poon, King Pan Ng, Chik Hong Kuick, Thuan Tong Tan, Lip Kun Tan, Michaela Su-fern Seng. Rapid production of clinical-grade SARS-CoV-2 specific T cells. Adv Cell Gene Ther. 2020 Oct;3(4):e101.
Khaing-Shwe Wah Pwint , Yunxin Chen, Colin Phipps Diong, Yeow-Tee Goh, Dixon Grant, Aloysius Ho, William Hwang, Sathish Kumar, Yuh-Shan Lee, Francesca Lim, Yvonne Loh, Chandramouli Nagarajan, Jeffrey Quek, Miriam Tao, Hein Than, Yeh-Ching Linn. Mobilization kinetics of peripheral blood stem cells with rescue plerixafor - real-world experience from a single center. Leukemia & lymphoma 2020; 61(7):1740-1743
Jeffrey Quek, Jing Jing Lee, Francesca Lorraine Lim, Colin Diong, Yeow Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Mickey Koh, Yvonne Loh, Yeh Ching Linn. Donor-type fresh frozen plasma is effective in preventing hemolytic reaction in major ABO incompatible allogeneic stem cell transplant. Transfusion. 2019 Jan;59(1):335–9.
Luah YH, Sundar Raj K, Koh MBC, Linn YC. A novel simplified method of generating cytomegalovirus-specific cytokine-induced killer cells of high specificity and superior potency with GMP compliance. Clin Immunol. 2019 Aug;205:83–92.
Cao L, Koh LP, Linn YC. Successful treatment of refractory autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation with bortezomib. Vol. 59, Leukemia & lymphoma. United States; 2018. p. 2500–2.
VV Maka, L-P Koh, C Diong, Y-T Goh, S Gopalakrishnan, A Ho, W Hwang, M Koh, F Lim, Z-Y Lim, Y Loh, M Poon, DR Del Rosario, B-C Tai, L-K Tan, P Tan and Y-C Linn. An exploration of the applicability of the refined disease risk index and its integration with other independent risk factors for individualized prognostication, Bone Marrow Transplantation 2017 Mar;52(3):363-371
Foon Yin Fung Wan Hui Wong, Seng Kok Ang, Hwee Ling Koh, Mei Ching Kun, Lai Heng Lee, Xiaomei Li, Heng Joo Ng, Chuen Wen Tan, Yan Zhao, Yeh Ching Linn. A randomized, double-blind, placebo- controlled study on the anti-haemostatic effects of Curcuma longa, Angelica sinensis and Panax ginseng. Phytomedicine. 2017 Aug;32:88–96.
Mya HT, Linn YC, Lim LC, Ng HJ. Chronic NK lymphocytosis identified by a distinct immunophenotypic pattern. Vol. 105, International journal of hematology. Japan; 2017. p. 3–4.
Lin Wang, John Allen, Colin Diong, Yeow-Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Francesca Lim, Lynette Oon, Thuan-Tong Tan, Yeh-Ching Linn, Ban Hock Tan. Respiratory virus infection after allogeneic hematopoietic stem cell transplant in a tropical center: Predictive value of the immunodeficiency scoring index. Transpl Infect Dis. 2017 Jun;19(3).e12693
Wei Zhou, Rehena Sultana, Colin Diong, Yeow-Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Liang-Piu Koh, Mickey Koh, Yvonne Loh, Patrick Tan, Yeh-Ching Linn. Long-term renal outcome after allogeneic hemopoietic stem cell transplant: A comprehensive analysis of risk factors in an Asian patient population. Clin Transplant. 2017 Apr;31(4).
Fung FY, Linn YC. Steroids in traditional Chinese medicine: what is the evidence? Singapore Med J. 2017 Mar;58(3):115–20.
Phipps C, Ho AY, Linn YC, Gopalakrishnan S, Ang AL, Lee JJ, et al. Thirty Years of Bone Marrow Transplantation in the Singapore General Hospital. Ann Acad Med Singapore. 2016 Jul;45(7):315–7.
Suck G, Linn YC, Tonn T. Natural Killer Cells for Therapy of Leukemia. Transfus Med hemotherapy Off Organ der Dtsch Gesellschaft fur Transfusionsmedizin und Immunhamatologie. 2016 Mar;43(2):89–95.
Poh SL, Linn YC. Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic blasts. Cancer Immunol Immunother. 2016 May;65(5):525–36.
Shen M, Linn Y-C, Ren E-C. KIR-HLA profiling shows presence of higher frequencies of strong inhibitory KIR-ligands among prognostically poor risk AML patients. Immunogenetics. 2016 Feb;68(2):133–44.
Chan W-C, Linn Y-C. A comparison between cytokine- and bead-stimulated polyclonal T cells: the superiority of each and their possible complementary role. Cytotechnology. 2016 Aug;68(4):735–48.
Liyuan Ma, Siguo Hao, Colin Diong, Yeow-Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Liang-Piu Koh, Mickey Koh, Zi-Yi Lim, Yvonne Loh, Michelle Poon, Lip-Kun Tan, Patrick Tan, Yeh-Ching Linn. WPSS is a strong prognostic indicator for clinical outcome of allogeneic transplant for myelodysplastic syndrome in Southeast Asian patients. Ann Hematol. 2015 May;94(5):761–9.
Liyuan Ma, Siguo Hao, Colin Diong, Yeow-Tee Goh, Sathish Gopalakrishnan, Aloysius Ho, William Hwang, Liang-Piu Koh, Mickey Koh, Zi-Yi Lim, Yvonne Loh, Michelle Poon, Lip-Kun Tan, Patrick Tan, Yeh-Ching Linn. Pre-transplant achievement of negativity in minimal residual disease and French-American-British L1 morphology predict superior outcome after allogeneic transplant for Philadelphia chromosome positive acute lymphoblastic leukemia: an analysis of Southeast Asian patients. Leuk Lymphoma. 2015 May;56(5):1362–9.
Fung FY, Linn YC. Developing traditional chinese medicine in the era of evidence-based medicine: current evidences and challenges. Evid Based Complement Alternat Med. 2015;2015:425037.
Ho X, Fook-Chong S, Linn Y-C. Natural killer cell receptor repertoire is comparable amongst newly diagnosed acute myeloid leukemia of different French-American-British subtypes, risk categories and chemosensitivities. Leuk Lymphoma. 2014 Feb;55(2):342–8.
Yeh-Ching Linn. Adoptive Immunotherapy with polyclonal T cells and natural killer cells for hematological malignancies: current status and future prospects. Int J Haematol Oncol 2013;2(4), 321-334
Yeh-Ching Linn, Hao-Xiang Yong, Madelaine Niam, Tsyr-Jong Lim, Sixian Chu, Alicia Choong, Charles Chuah, Yeow-Tee Goh, William Hwang, Yvonne Loh, Heng-Joo Ng, Garnet Suck, Marieta Chan, Mickey Koh. A phase I/II clinical trial of autologous cytokine-induced killer cells as adjuvant immunotherapy for acute and chronic myeloid leukemia in clinical remission. Cytotherapy. 2012 Aug;14(7):851–9.
Yeh-ching LINN, Madelaine NIAM, Sixian CHU, Alicia CHOONG, Hao-xiang YONG, Kee-khiang HENG, William HWANG, Yvonne LOH , Yeow-tee GOH, Garnet SUCK, Marieta CHAN, Mickey KOH. The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies. Bone Marrow Transplantation 2012 Jul;47(7):957-66
Yong HX, Linn YC, Ong KH, Tan D. Chemoimmunotherapy with bendamustine hydrochloride and alemtuzumab demonstrates synergism in T-prolymphocytic leukemia. Vol. 36, Leukemia research. England; 2012. p. e163-5.
Mohan BP, How G, Loh Y, Linn YC. Sorafenib monotherapy gives sustainable suppression of FLT3 clone in untreated patients with FLT3-internal tandem duplication positive acute myeloid Leukaemia. Vol. 157, British journal of haematology. England; 2012. p. 131–2.
Linn Y-C, Lu J, Lim L-C, Sun H, Sun J, Zhou Y, et al. Berberine-induced haemolysis revisited: safety of Rhizoma coptidis and Cortex phellodendri in chronic haematological diseases. Phytother Res. 2012 May;26(5):682–6.
Linn Y-C, Lu J, Lim L-C, Sun H, Sun J, Zhou Y. Traditional Chinese herbal medicine in the supportive management of patients with chronic cytopaenic marrow diseases -- a phase I/II clinical study. Complement Ther Clin Pract. 2011 Aug;17(3):152–6.
Niam M, Linn Y-C, Fook Chong S, Lim T-J, Chu S, Choong A, et al. Clinical scale expansion of cytokine-induced killer cells is feasible from healthy donors and patients with acute and chronic myeloid leukemia at various stages of therapy. Exp Hematol. 2011 Sep;39(9):897-903.e1.
Linn YC, Hui KM. Cytokine-induced NK-like T cells: from bench to bedside. J Biomed Biotechnol. 2010;2010:435745.
YC Linn, CY Phang, TJ Lim, SF Chong, KK Heng, JJ Lee, Y Loh, W Hwang, YT Goh and M Koh. Effect of missing killer-immunoglobulin-like receptor ligand in recipients undergoing HLA full matched, non-T depleted sibling donor transplantation ----- A single institution experience of 151 Asian patients. Bone marrow transplantation 2010, 45: 1031–1037
AS Babatunde, DCL Tan, KK Heng, JJ Lee, YSM Loh, WYK Hwang, MBC Koh, YT Goh and YC Linn. Characterization of hemopoietic engraftment kinetics and development of secondary cytopenia in AML post Auto-SCT and its correlation with survival outcome. Bone Marrow Transplantation (2009), 44:175-183
Yeh C. Linn, Siew Kee J. Lau, Bee H. Liu, Lee H. Ng, Hao X. Yong and Kam M. Hui. Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell. Immunology 2009, 126: 423–435
Hwang WYK, Samuel M, Tan D, Koh LP, Lim W, Linn YC. A meta-analysis of unrelated donor umbilical cord blood transplantation versus unrelated donor bone marrow transplantation in adult and pediatric patients. Biol blood marrow Transplant J Am Soc Blood Marrow Transplant. 2007 Apr;13(4):444–53.
Linn YC, Wang SM, Hui KM. Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays. Exp Hematol. 2005 Jun;33(6):671–81.
Q Zhu, D C L Tan, M Samuel, E S Y Chan and Y C Linn. Fludarabine in Comparison to Alkylator-based Regimen as Induction Therapy for Chronic Lymphocytic Leukemia : A Systematic Review and Meta-analysis. Leukemia and lymphoma, 2004, 45(11) :2239-2245
Linn YC and Hui KM. Cytokine-induced killer cells : NK –like T cells with cytolytic specificity against leukemia. Leukemia and Lymphoma, 2003, 44(9) : 1457-1462
Linn YC, Lau LC, Hui KM. Generation of Cytokine-induced Killer Cells from Leukemia Samples with in vitro Cytotoxicity against Autologous and Allogeneic Leukemic Blasts. British J of Haematology, 2002, 116 ( 1) : 78-86
J C Alvarnas, YC Linn, E G Hoppe, R S Negrin. Expansion of Cytotoxicity CD3+CD56+ Cells from Peripheral Blood Progenitor Cells of Patients Undergoing Autologous Hematopoietic Cell Transplantation. Biol of Blood and Marrow Transplantation 2001, 7 : 216 – 222
Y C Linn, K K Heng, Rohimah S, Y T Goh. Peripheral Blood Progenitor Cell Mobilization in Three Groups of Subjects: A comparison of Leukapheresis Yield and Timing. Journal of Clinical Apheresis, 2000, 15 : 217 – 223
Y C Linn, Y T Goh, P Tan. Relapse of Leukemia and Lymphoma after Marrow Transplant: A Review of Cases with Extramedullary Relapse. Leukemia and Lymphoma, 2000, vol 38 (1 – 2 ), pp137 – 146
Y C Linn, S L Tien. Haemophagocytosis in Bone Marrow Aspirate – A Review of the Clinical Course of Ten Cases. Acta Haematologica 1995; 94:182-191
Linn YC, Prakash P, Ong YW A study of platelet alloantibody in multiply-transfused haematology patients. Ann Acad Med Singapore. 1995;24(2):305-11.
Linn YC, Tien SL. Detection of protein C or protein S deficiency in patients on warfarin therapy--a study of nine patients. Ann Acad Med Singapore. 1994;23(5):775-80.