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Clin Assoc Prof Tien Sim Leng

MBBS, MMed (Int Med), FRCPA, FAMS

Senior Consultant

Singapore General Hospital

Specialty: Haematology, Haematology

Clinical Interest: Thrombosis and Haemostasis, Laboratory Haematology

Conditions Treated by this Doctor:
Acute Lymphocytic Leukemia (ALL), Aplastic Anaemia, Bleeding Disorders, Chronic lymphocytic leukemia, Chronic Myeloid Leukemia, Deep Vein Thrombosis, Deep Vein Thrombosis, Essential Thrombocythemia and Myelofibrosis, Haematology, Haemophilia and other bleeding disorders, Hemophilia, Multiple Myeloma, Myelodysplastic Syndrome, Myelofibrosis, Polycythemia Vera, Thalassaemia.

Clinical Appointments

Head, SGH Blood Bank & Cytogenetics in the Department of Clinical Pathology & Molecular Pathology Clinical Pathology Singapore General Hospital
Senior Consultant SingHealth Duke-NUS Blood Cancer Centre
Senior Consultant Haematology Singapore General Hospital
Senior Consultant National Cancer Centre Singapore

Academic Appointments

Clinical Associate Professor, Yong Loo Ling School of Medicine, National University Singapore
Adjunct Assistant Professor, Duke-NUS Medical School

Profile

A/Prof Tien was trained in both Clinical and Laboratory Haematology, including Transfusion Medicine. After graduating from National University of Singapore with MBBS and Master of Medicine (Internal Medicine), he obtained Fellowship from the Royal College of Australasia in Pathology (Haematology) and Fellowship from the Academy of Medicine, Singapore in Haematology. He is currently a Senior Consultant in the Department of Haematology and Director of Haematology laboratory, and Head, SGH Blood Bank & Cytogenetics in the Department of Clinical Pathology & Molecular Pathology, Singapore General Hospital. He is also the Director of SGH Haemophilia Centre, recognised by the World Federation of Haemophilia as an International Haemophilia Training Centre.

He has concurrent appointments with the National University of Singapore, YLL School of Medicine as a Clinical Associate Professor and Duke-NUS Medical school as an Adjunct Associate Professor and former appointment with Nanyang Technological University, School of Biological Sciences as Adjunct Associate Professor.

Besides general clinical and laboratory haematology, he has an active interest in Coagulation, esp. Bleeding Disorders, and Transfusion Medicine. His other interests include Blood / Bone marrow Morphology and Cytogenetics. He received HMDP Fellowship for training in Advanced Haematology at St Vincent’s Hospital, Sydney, Australia and later HMDP Fellowship for training in Cytogenetics in Mayo Clinic, USA. A/Prof Tien was the President of the 5th Congress of the Asian Pacific Society on Thrombosis and Haemostasis held in Singapore in 2008. He was Chairman of Organising Committee for International Haemophilia Course, Malmo Programme held in Singapore 2013.

To-date, he has at least 220 abstracts and 80 publications in international peer-reviewed journals. He has been awarded at least 45 Research Grants. He is a reviewer of Annals, Academy of Medicine, Singapore Medical Journal, Thrombosis Journal, NMRC and BMRC Grants.

Education

Professional Appointments and Committee Memberships

Council Member of Asia-Pacific Society on Thrombosis and Haemostasis
Council Member of ASEAN Division of World Federation of Haemophilia
Chairman of SGH Blood Transfusion Committee

Awards

SGH Quality Service Award 2004 and SGH Excellence Service Award (Silver) 2008
Singhealth Quality Service Award (Gold) in 2015 and Award (Star) in 2016
Singapore Accreditation Council Assessor GOLD Award 2019
Singapore Medical Journal Recognition Awards for Reviewing with Distinction 2006, 2007 and 2008

Research Interests

Publications

Chng KZ, Ng YC, Namgung B, Tan JKS, Park S, Tien SL, et al. Assessment of transient changes in oxygen diffusion of single red blood cells using a microfluidic analytical platform. Commun Biol. 2021 Mar;4(1):271.
Chen C, Lim AST, Lau LC, Lim TH, Heng EYH, Tien SL. Implementation of cytogenomic microarray with plasma cell enrichment enables better abnormality detection and risk stratification in patients with plasma cell neoplasia than conventional cytogenetics and fluorescence in situ hybridization. Cancer Genet. 2021 Apr;252–253:25–36.
Chen C, Heng EYH, Lim AST, Lau LC, Lim TH, Wong GC, et al. Chromosomal microarray analysis is superior in identifying cryptic aberrations in patients with acute lymphoblastic leukemia at diagnosis/relapse as a single assay. Int J Lab Hematol. 2019 Aug;41(4):561–71.
Ng YC, Namgung B, Tien SL, Leo HL, Kim S. Symmetry recovery of cell-free layer after bifurcations of small arterioles in reduced flow conditions: effect of RBC aggregation. Am J Physiol Heart Circ Physiol. 2016 Aug;311(2):H487-97.
Lim TH, Lim AST, Thike AA, Tien SL, Tan PH. Implications of the Updated 2013 American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations on Human Epidermal Growth Factor Receptor 2 Gene Testing Using Immunohistochemistry and Fluorescence In Situ Hybridization for Breast Cancer. Arch Pathol Lab Med. 2016 Feb;140(2):140–7.
Lim AST, Krishnan S, Lim TH, See K, Ng YJ, Tan YM, et al. Amplification of 1q21 and other abnormalities in multiple myeloma patients from a tertiary hospital in singapore. Indian J Hematol blood Transfus an Off J Indian Soc Hematol Blood Transfus. 2014 Dec;30(4):253–8.
Liaw FPS, Lau LC, Lim AST, Lim TH, Lee GY, Tien SL. CpG Oligonucleotide and Interleukin 2 stimulation enables higher cytogenetic abnormality detection rates than 12-o-tetradecanolyphorbol-13-acetate in Asian patients with B-cell chronic lymphocytic leukemia (B-CLL). Int J Hematol. 2014 Dec;100(6):545–53.
Ho LP, Yit PS, Ng LH, Linn YC, Zhao Y, Sun L, et al. The road to memory: an early rest for the long journey. J Immunol. 2013 Dec;191(11):5603–14.
Lim AST, Lim TH, See KHS, Ng YJ, Tan YM, Choo NSL, et al. Cytogenetic and molecular aberrations of multiple myeloma patients: a single-center study in Singapore. Chin Med J (Engl). 2013;126(10):1872–7.
Kee SK, See VH-L, Chia P, Tan WC, Tien SL, Lim STA. Differential outcomes in an extended family with constitutional t(11;22)(q23.3;q11.2). Vol. 2, Journal of pediatric genetics. 2013. p. 37–41.
Yiu RC, Tien S-L. Cold agglutinin disease with prolymphocytic leukemia. Blood. 2012 May;119(22):5069.
Ahmed SS, Iqbal J, Thike AA, Lim AST, Lim TH, Tien SL, et al. HER2/neu revisited: quality and interpretive issues. J Clin Pathol. 2011 Feb;64(2):120–4.
Lim AST, Chen TJ, Lim TH, Tan M, Lau LC, Lim P, et al. Bone marrow cytogenetics workup: Application of lean management system to determine if additional cell workup is helpful and necessary to analysis. Ann Acad Med Singapore. 2010 Sep;39(9):696–9.
Tan YS, Ng LG, Yip SK-H, Tay M-H, Lim AS-T, Tien SL, et al. Synovial sarcoma of the kidney: a report of 4 cases with pathologic appraisal and differential diagnostic review. Anal Quant Cytol Histol. 2010 Aug;32(4):239–45.
Lau L-C, Lim P, Lim Y-C, Teng L-M, Lim T-H, Lim L-C, et al. Occurrence of trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a patient with B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 Sep;185(2):95–101.
Lim AST, Lim TH, Kee SK, Chia P, Raman S, Eu ELP, et al. Holoprosencephaly: an antenatally-diagnosed case series and subject review. Ann Acad Med Singapore. 2008 Jul;37(7):594–7.
Tan D, Lau LC, Teng LM, Sane S, Lim TH, Tien SL. Loss of the extra chromosome 21 in a patient with Down syndrome and myelodysplasia. Cancer Genet Cytogenet. 2008 Jan;180(1):79–82.
Ho L-P, Ho Y-K, Tien S-L. Case report: induction of immune tolerance to factor VIII inhibitor after a major operation. Ann Acad Med Singapore. 2007 Jun;36(6):431–4.
Lau L-C, Kee S-K, Tien S-L, Koh Mickey B-C. Trisomy 8 as sole cytogenetic abnormality in a case of chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2007 Jan;172(1):66–9.
Chuah C, Lim TH, Lim AST, Tien SL, Lim CH, Soong R, et al. Dasatinib induces a response in malignant thymoma. Vol. 24, Journal of clinical oncology: official journal of the American Society of Clinical Oncology. United States; 2006. p. e56-8.
Lim TH, Lim AST, Tien SL. A novel isoderivative chromosome 20 in a patient with chronic myelomonocytic leukemia. Vol. 170, Cancer genetics and cytogenetics. United States; 2006. p. 80–2.
Wong C-H, Song C, Heng K-S, Kee IHC, Tien S-L, Kumarasinghe P, et al. Plasma free hemoglobin: a novel diagnostic test for assessment of the depth of burn injury. Plast Reconstr Surg. 2006 Apr;117(4):1206–13.
Jaichandran S, Yap STB, Khoo ABM, Ho LP, Tien SL, Kon OL. In vivo liver electroporation: optimization and demonstration of therapeutic efficacy. Hum Gene Ther. 2006 Mar;17(3):362–75.
Chow W-C, Tien S-L, Tan C-K, Lui H-F, Vathsala A, Ng H-S. Treatment of chronic hepatitis C in patients with end-stage renal disease and hemophilia--the Singapore experience. Intervirology. 2006;49(1–2):107–11.
Lau L-C, Koh L-P, Lim T-H, Loo L-E, Tien S-L. A cryptic three-way translocation involving chromosomes 8, 14, and 21 in a case of acute myeloid leukemia subtype M1. Vol. 163, Cancer genetics and cytogenetics. United States; 2005. p. 86–90.
Kian CTS, Leng TS. The Singapore approach to human stem cell research, therapeutic and reproductive cloning. Bioethics. 2005 Jun;19(3):290–303.
Lee GY, Christina S, Tien SL, Ghafar ABA, Hwang W, Lim LC, et al. Acute promyelocytic leukemia with PML-RARA fusion on i(17q) and therapy-related acute myeloid leukemia. Cancer Genet Cytogenet. 2005 Jun;159(2):129–36.
Tien S-L, Rudduck-Sivaswaren C, Lim P, Lim E, Lie DKH, Tan PHC, et al. High incidence of derivative chromosome arm 9q deletions in Asian chronic myelogenous leukemia. Vol. 42, Genes, chromosomes & cancer. United States; 2005. p. 433–4.
Long YC, Jaichandran S, Ho LP, Tien SL, Tan SY, Kon OL. FVIII gene delivery by muscle electroporation corrects murine hemophilia A. J Gene Med. 2005 Apr;7(4):494–505.
Enjeti AK, Tien SL, Sivaswaren CR. Cytogenetic abnormalities in de novo acute myeloid leukemia in adults: relation to morphology, age, sex and ethnicity - a single center study from Singapore. Hematol J Off J Eur Haematol Assoc. 2004;5(5):419–25.
Siew-Gek Lee A, Rudduck-Sivaswaren C, Khun-Hong Lie D, Li-Ming Chua C, Tien S-L, Morsberger L, et al. Overlapping deletion regions at 11q23 in myelodysplastic syndrome and chronic lymphocytic leukemia, characterized by a novel BAC probe set. Cancer Genet Cytogenet. 2004 Sep;153(2):151–7.
Lee AS-G, Lie DK-H, Tien S-L, Rudduck-Sivaswaren C. Increased amplification proximal to the MLL gene in acute myeloid leukemia. Int J Mol Med. 2004 Jan;13(1):63–7.
Selvarajan S, Bay B-H, Mamat SB, Choo A, Chuah K-L, Sivaswaren CR, et al. Detection of HER2/neu gene amplification in archival paraffin-embedded breast cancer tissues by fluorescence in situ hybridization. Histochem Cell Biol. 2003 Sep;120(3):251–5.
Ng SB, Ahmed Q, Tien SL, Sivaswaren C, Lau LC. Primary pleural synovial sarcoma. A case report and review of the literature. Arch Pathol Lab Med. 2003 Jan;127(1):85–90.
Wong JT-Y, Chan DK-L, Wong K-Y, Tan M, Rudduck C, Tien S-L. Smith-Magenis syndrome and cyanotic congenital heart disease: a case report. Clin Dysmorphol. 2003 Jan;12(1):73–4.
Selvarajan S, Bay B-H, Choo A, Chuah K-L, Sivaswaren CR, Tien S-L, et al. Effect of fixation period on HER2/neu gene amplification detected by fluorescence in situ hybridization in invasive breast carcinoma. J Histochem Cytochem Off J Histochem Soc. 2002 Dec;50(12):1693–6.