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Dr Carmody David

MB BCh BAO, LRCPI & SI, MRCP(UK), MD

Senior Consultant

Singapore General Hospital

Specialty: Endocrinology, Endocrinology

Clinical Interest: Diabetes, General Endocrinology

Conditions Treated by this Doctor:
Type 2 Diabetes Mellitus.

Clinical Appointments

Senior Consultant SingHealth Duke-NUS Diabetes Centre
Senior Consultant Endocrinology Singapore General Hospital

Academic Appointments

Posting Lead- Endocrinology, Lee Kong Chian School of Medicine
Adjunct Instructor- Endocrinology, Duke NUS School of Medicine

Profile

David graduated with an MB BCh BAO (Hons) from the Royal College of Surgeons in Ireland (RCSI) in 2004. He completed advanced specialist training in both Internal Medicine and Endocrinology through the Royal College of Physicians in Ireland in 2016. He was awarded his postgraduate research degree (MD) in 2017 by RCSI and his thesis was entitled “Monogenic Diabetes: Gene directed therapy and mutation specific phenotypes”.

His current clinical and research interests focus primarily on atypical forms of diabetes mellitus and complications of diabetes mellitus.

Education

MD RCSI 2017
Certificate of Satisfactory Completion of Specialist Training (CSCST) in General Internal Medicine and Endocrinology 2016
MRCP (UK) 2008
MB BCh BAO LRCP&SI (Ireland) 2004

Professional Appointments and Committee Memberships

Awards

2015 University of Chicago Pediatrics Research Day

Best Translational Research Award

2014 Endocrine Society’s 96th Annual Meeting

Presidential Poster Competition Award Winner

Research Interests

Atypical Diabetes Mellitus
Monogenic Diabetes Mellitus
Complications of Diabetes Mellitus

Publications

A selection of peer-reviewed publications in the primary literature (Published Reviews, Book Chapters and Commentaries not included)

Letourneau LR, Carmody D, Wroblewski K, Denson AM, Sanyoura M, Naylor RN, Philipson LH, Greeley SAW. Diabetes Presentation in Infancy: High Risk of Diabetic Ketoacidosis. Diabetes Care. 2017 Aug 4. PMID: 28779000.
Greeley SA, Zielinski MC, Poudel A, Ye H, Berry S, Taxy JB, Carmody D, Steiner DF, Philipson LH, Wood JR, Hara M. Preservation of Reduced Numbers of Insulin-Positive Cells in Sulfonylurea-Unresponsive KCNJ11-Related Diabetes. J Clin Endocrinol Metab. 2017 Jan 1;102(1):1-5. PubMed PMID: 27802092.
Carmody D, Pastore AN, Landmeier KA, Letourneau LR, Martin R, Hwang JL, Naylor RN, Hunter SJ, Msall ME, Philipson LH, Scott MN, Greeley SA. Patients with KCNJ11-related diabetes frequently have neuropsychological impairments compared with sibling controls. Diabet Med. 2016 Oct;33(10):1380-6. PubMed PMID: 27223594.
Carmody D, Naylor RN, Bell CD, Berry S, Montgomery JT, Tadie EC, Hwang JL, Greeley SA, Philipson LH. GCK-MODY in the US National Monogenic Diabetes Registry: frequently misdiagnosed and unnecessarily treated. Acta Diabetol. 2016 Oct;53(5):703-8. PubMed PMID: 27106716
Landmeier KA, Lanning M, Carmody D, Greeley SA, Msall ME. ADHD, learning difficulties and sleep disturbances associated with KCNJ11-related neonatal diabetes. Pediatr Diabetes. 2016 Aug 24. PubMed PMID: 27555491.
Behan LA, Carmody D, Rogers B, Hannon MJ, Davenport C, Tormey W, Smith D, Thompson CJ, Stanton A, Agha A. Low-dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotrophin-deficient hypopituitary male patients. Eur J Endocrinol. 2016 Jun;174(6):791-9. PubMed PMID: 27025241.
Alkorta-Aranburu G, Sukhanova M, Carmody D, Hoffman T, Wysinger L, Keller-Ramey J, Li Z, Johnson AK, Kobiernicki F, Botes S, Fitzpatrick C, Das S, Del Gaudio D. Improved molecular diagnosis of patients with neonatal diabetes using a combined next-generation sequencing and MS-MLPA approach. J Pediatr Endocrinol Metab. 2016 May 1;29(5):523-31. PubMed PMID: 26894574.
Carmody D, Ladsaria SS, Buikema RK, Semple RK, Greeley SA. Successful rhIGF1 treatment for over 5 years in a patient with severe insulin resistance due to homozygous insulin receptor mutation. Diabet Med. 2016 Mar;33(3):e8-e12. PubMed PMID: 26262567.
Perrone ME, Carmody D, Philipson LH, Greeley SA. An online monogenic diabetes discussion group: supporting families and fueling new research. Transl Res. 2015 Nov;166(5):425-31. PubMed PMID: 26184072.
Carmody D, Park SY, Ye H, Perrone ME, Alkorta-Aranburu G, Highland HM, Hanis CL, Philipson LH, Bell GI, Greeley SA. Continued lessons from the INS gene: an intronic mutation causing diabetes through a novel mechanism. J Med Genet. 2015 Sep;52(9):612-6. PubMed PMID: 26101329.
Thurber BW, Carmody D, Tadie EC, Pastore AN, Dickens JT, Wroblewski KE, Naylor RN, Philipson LH, Greeley SA; United States Neonatal Diabetes Working Group.. Age at the time of sulfonylurea initiation influences treatment outcomes in KCNJ11-related neonatal diabetes. Diabetologia. 2015 Jul;58(7):1430-5. PubMed PMID: 25877689.
Carmody D, Naylor RN, Philipson LH. Insulin dosing in pediatric diabetic ketoacidosis: where to start? JAMA. 2015 Jun 9;313(22):2274-5. PubMed PMID: 26057288.
Carmody D, Beca FA, Bell CD, Hwang JL, Dickens JT, Devine NA, Mackay DJ, Temple IK, Hays LR, Naylor RN, Philipson LH, Greeley SA. Role of noninsulin therapies alone or in combination in chromosome 6q24-related transient neonatal diabetes: sulfonylurea improves but does not always normalize insulin secretion. Diabetes Care. 2015 Jun;38(6):e86-7. PubMed PMID: 25998302.
Carmody D, Lindauer KL, Naylor RN. Adolescent non-adherence reveals a genetic cause for diabetes. Diabet Med. 2015 Jun;32(6):e20-3. PubMed PMID: 25494859.
Carmody D, Bell CD, Hwang JL, Dickens JT, Sima DI, Felipe DL, Zimmer CA, Davis AO, Kotlyarevska K, Naylor RN, Philipson LH, Greeley SA. Sulfonylurea treatment before genetic testing in neonatal diabetes: pros and cons. J Clin Endocrinol Metab. 2014 Dec;99(12):E2709-14. PubMed PMID: 25238204.
Alkorta-Aranburu G, Carmody D, Cheng YW, Nelakuditi V, Ma L, Dickens JT, Das S, Greeley SA, del Gaudio D. Phenotypic heterogeneity in monogenic diabetes: the clinical and diagnostic utility of a gene panel-based next-generation sequencing approach. Mol Genet Metab. 2014 Dec;113(4):315-20. PubMed PMID: 25306193.
Shalev SA, Tenenbaum-Rakover Y, Horovitz Y, Paz VP, Ye H, Carmody D, Highland HM, Boerwinkle E, Hanis CL, Muzny DM, Gibbs RA, Bell GI, Philipson LH, Greeley SA. Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in IER3IP1: insights into the natural history of a rare disorder. Pediatr Diabetes. 2014 May;15(3):252-6. PubMed PMID: 24138066.
Naylor RN, John PM, Winn AN, Carmody D, Greeley SA, Philipson LH, Bell GI, Huang ES. Cost-effectiveness of MODY genetic testing: translating genomic advances into practical health applications. Diabetes Care. 2014;37(1):202-9. PubMed PMID: 24026547.
Carmody D, Philipson L. Neonatal diabetes: the brain comes into focus. Lancet Diabetes Endocrinol. 2013 Nov;1(3):167-8. PubMed PMID: 24622356.
Mylotte D, Kavanagh GF, Peace AJ, Tedesco AF, Carmody D, O'Reilly M, Foley DP, Thompson CJ, Agha A, Smith D, Kenny D. Platelet reactivity in type 2 diabetes mellitus: a comparative analysis with survivors of myocardial infarction and the role of glycaemic control. Platelets. 2012;23(6):439-46. PubMed PMID: 22150374.
Carmody D, Doyle A, Firth RG, Byrne MM, Daly S, Mc Auliffe F, Foley M, Coulter-Smith S, Kinsley BT. Teenage pregnancy in type 1 diabetes mellitus. Pediatr Diabetes. 2010 Mar;11(2):111-5. PubMed PMID: 19968816.

Research Trials

Tags: Endocrinology, Endocrinology, Diabetes, General Endocrinology, Type 2 Diabetes Mellitus