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Singapore General Hospital Research & Innovation Enablers Clinical Translational Sciences

Clinical Translational Sciences (CTS) Core

Synonym(s):

Driving Medical Research Breakthroughs with Clinical Translational Sciences

The Department of Clinical Translational Research (DCR) at Singapore General Hospital (SGH) supports medical discovery through research laboratories and platforms in Genomics, Proteomics, Immunology, and Imaging. Since 2012, our Clinical Translational Sciences (CTS) Core has helped transform laboratory discoveries into practical healthcare solutions.

Our research environment connects 12 department laboratories across Academic Clinical Programs, including Medicine, Surgery, Neuroscience, and Musculoskeletal Sciences, enabling collaboration and innovation.

Our Research Capabilities

Genomics Platform

Our genomics capabilities encompass DNA sequencing, real-time q-PCR, and digital PCR technologies. The platform supports comprehensive genetic analysis, including SNP genotyping, microRNA studies, and gene expression analysis, complemented by DNA and RNA extraction facilities and gel imaging capabilities.

Proteomics Platform

We offer extensive protein analysis through both one-dimension and two-dimension protein electrophoresis. Our facilities support protein expression studies, isolation, and purification processes. The platform includes advanced systems for quantitative multi-analyte profiling of cytokines, cell signalling analysis, and phosphoprotein detection, supported by fluorescence and luminescence plate readers, chemiluminescence imaging systems, and sophisticated spectrophotometers.

Immunology Platform

The immunology platform facilitates comprehensive research into immune responses and pathological mechanisms. Through advanced immunoassays and flow cytometry, we support studies in malignancies, autoimmune conditions, and infectious diseases. Our equipment enables detailed phenotyping and immune response monitoring across various disease states.

Imaging Platform

Our imaging capabilities combine confocal and conventional fluorescence microscopy with robust image analysis resources. Researchers can conduct detailed studies of both fixed and live cells, with facilities supporting both unlabelled and fluorescently labelled samples.

Strategic Partnerships

Our work integrates closely with several key units. We collaborate with the Clinical Trials Research Centre for biomarker-directed clinical trials, work alongside the Health Services Research & Data Management Core for clinical correlation studies, and partner with the Medical Technology & Device Development Core to explore innovative solutions in healthcare delivery.
Contact Information

Singapore General Hospital, Academia
Level 9, Discovery Tower

+65 6576 2032

Projects 

A significant development in our research infrastructure is the establishment of Singapore's first hospital-based Good Manufacturing Practice (GMP) facility for cell therapy research, scheduled for completion in Q4 2026. This facility will enable us to conduct Phase 1 and 2 clinical trials in cell therapy, maintain rigorous quality control standards, and build local expertise in cellular therapeutics. The development represents our commitment to advancing therapeutic research in Singapore. 

Goals 

Our vision extends beyond in-house research to building meaningful partnerships with biotechnology and pharmaceutical companies. These collaborations support the sustainability of our GMP facility operations while advancing cell therapy development in Singapore. 

Through industry partnerships, we create opportunities for shared success. Companies gain access to our GMP facility for cell therapy development, while we maintain operational capabilities through strategic cost-sharing arrangements. These collaborations provide our research teams with industry exposure and strengthen Singapore's cell therapy ecosystem through effective public-private engagement. 

This collaborative model aims to create a sustainable framework that supports continued innovation in cell therapy research. By combining resources and expertise, we work to ensure the facility remains a viable and productive research asset for years to come. 

Collaborate 

We welcome partnerships with industry players who share our commitment to advancing medical research. Our collaboration model focuses on creating sustainable operations while maximising resource utilisation. By working together, partners gain access to our facilities and expertise, while contributing to Singapore's growing cell therapy research capabilities. These partnerships enable knowledge exchange and drive technological advancement in healthcare. 

Services 

Our scientific team provides end-to-end research support, from initial concept through to final analysis. We offer comprehensive services including: 

Research Design and Planning  Budget planning and management  Access to specialised equipment 
Experimental design and setup  Laboratory Services  Core laboratory facilities 
Protocol development and review  Sample processing  Hot lab bench space 
Experimental data analysis  Analysis and Storage  Bioinformatics support 
Biospecimen storage Tissue banking   

 

Find out more about our services Find out more about our researchers

Connect with Us 

Ready to explore how we can support your research?  

To begin your research journey with us: 

  1. Download our service request form (for Singhealth staff only) 

  2. Complete the required details 

  3. Email the form to dcr.research.consultation@sgh.com.sg

Non-SingHealth staff can reach out to us at dcr.research.consultation@sgh.com.sg. Our team will review your request and respond promptly to discuss how we can support your research needs. 

Please note that selected services carry a nominal fee. 

 

Let's Connect!

 

Ready to be part of our transformative journey? 

Innovation waits for no one. Get in touch with us.

Contact Us

 
SGH Enablers

Health Services Research Unit (HSRU)

Optimizes healthcare delivery through evidence-based research and outcome studies

Clinical Innovation and Technology Unit (CITU)

Develops technological solutions to address clinical challenges in healthcare

Clinical Trials & Research Centre (CTRC)

Provides end-to-end support for clinical trials and research studies

Department of Clinical Translational Research (DCR)

Transforms laboratory discoveries into practical clinical treatments and applications

Biomechanics Lab

Studies movement science to improve patient rehabilitation and musculoskeletal care

Data Science and Artificial Intelligence Laboratory (DSAIL)

Applies AI and analytics to enhance healthcare delivery outcomes

Pathological Sciences

Advances disease diagnostics through innovative pathology research and methods

Radiological Sciences

Develops advanced imaging techniques for improved diagnosis and treatment

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