Biologics act as precision tools in severe asthma treatment, intercepting specific inflammatory pathways to provide relief when conventional medications fall short.
Biologics, also known as monoclonal antibodies, work by binding to and blocking the function of a specific target molecule. They block pathways that lead to inflammation that causes asthma symptoms.
Types of biologics available in SGH:
All the approved biologic agents for severe asthma have shown to reduce exacerbations and hospitalisations, improve lung function, asthma control and quality of life, and reduce the use of systemic corticosteroids, with a favourable safety profile (Results from meta-analysis of 48 randomised control trials involving 16350 patients*).
The effect of the biologics was greater overall in the subgroups of participants with features of T2-high inflammation.
Source: Kyriakopoulos C, Gogali A, Markozannes G, Kostikas K. Biologic agents licensed for severe asthma: a systematic review and meta-analysis of randomised controlled trials. Eur Respir Rev. 2024 Apr 24;33(172):230238.
Studies have shown that biologics are generally safe and well-tolerated. Common side effects include soreness at injection site, headache, sore throat and fatigue. They are usually mild and self-limiting. Very rarely, some patients may develop allergic reactions (swelling of eyes or lips, rashes, light-headedness or difficulty breathing).
